| 中文名稱 | 荷仕登牛的牛白血球附著能力缺乏症，BLAD |
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| 英文名稱 | Bovine leukocyte adhesion deficiency, blad, in holstein cattle |
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| 建立日期 | 2007/11/01 |
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| 更新日期 | 2007/11/01 |
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| 中文描述 | 牛白血球附著能力缺乏症（BLAD）是一種影響荷仕登牛的自體隱性基因問題。白血球表面的β2整合蛋白附著分子表現受限制，干擾白血球附著和白血球由血管系統移動到感染的部位。有隱性等位基因同型合子的牛隻對感染感受性較高，可能引起早期死亡或持續的嗜中性球過多症。人工受精的公牛會檢查BLAD，因為避免帶原公牛廣泛使用，臨床疾病已經逐漸較少見了。可由DNA聚合酶連鎖反應分析確診。 |
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| 英文描述 | Bovine leukocyte adhesion deficiency (BLAD) is an autosomal recessive genetic disorder affecting Holstein cattle. Beta-2-integrin adhesion molecules on the surface of leukocytes have limited expression, hindering leukocyte adherence and passage from the vascular system to a site of infection. Cattle that are homozygous for the recessive allele are more susceptible to infection that might lead to premature death and have a persistent neutrophilia. Bulls in artificial insemination are screened for BLAD and clinical disease has become progressively more rare as carrier bulls were eliminated from widespread use. The diagnosis can be confirmed by DNA-polymerase chain reaction analysis. |
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