| 英文描述 | Erythrocyte pyruvate kinase deficiency is inherited as a recessive trait in dogs and cats. The hemolytic disease is a disorder of young animals, while those surviving to 2-3 years of age are affected with myelofibrosis and osteosclerosis, which further impair erythropoesis, and eventually lead to death from anemia or hepatic failure. Dx by signs, RBC indices (hemolytic disorder characterized by macrocytic-hypochromic highly regenerative anemia with some poikilolcytosis), enzyme assays, and genetic testing. |
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