| 中文名稱 | 犬貓的尿崩症 |
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| 英文名稱 | Diabetes insipidus in dogs and cats |
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| 建立日期 | 2007/11/01 |
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| 更新日期 | 2007/11/01 |
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| 中文描述 | 此種疾病是由PU/PD值所描述,其可能起因於腦下垂體製造不足的抗利尿激素,或是位於腎臟的目標細胞失去作用去對ADH在體內的循環做出反應,也可能是因為缺少了水離子通道蛋白.大多數的案例是自發性的,一般起因於腦垂體的原因可能是因為腦垂體腫瘤,囊苞,肉芽腫,外傷,區域性感染導致壓縮到腦垂體,而神經病學的徵兆隨即會出現.腎臟的外型狀態可能與子宮蓄膿,一些肝臟的疾病,腎上腺功能亢進症,腎盂腎炎,低血鉀症,腎上腺皮質功能低下症,甲狀腺機能亢進,肢端肥大症,腎臟的疾病,瘤的形成以及一些藥物有關聯.在年輕的狗身上會發生先天性的腎性尿崩症.診斷可藉由病症,刪去法去除其他病症,脫水試驗,ADH反應試驗.腎性尿崩症部會對外因性的ADH產生反應.動物不能喝水或是被限制喝水都會有產生高血鈉及次級神經病學徵兆如昏睡的危險. |
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| 英文描述 | This disease is characterized by PU/PD and may result from inadequate pituitary production of antidiuretic hormone or failure of target cells in the kidney to respond to circulating levels of ADH, probably due to lack of the water-channel protein aquaporin. Most cases are idiopathic, but common causes of the pituitary form are pituitary neoplasia, cysts, granulomas, trauma, or localized infection which result in compression of the pituitary; neurologic signs often follow rapidly. Nephrogenic form has been associated with pyometra, severe hepatic disease, hyperadrenocorticism, pyelonephritis, hypokalemia, hypoadrenocorticism, hyperthyroidism, acromegaly, renal disease, neoplasia, and several drugs; congenital nephrogenic diabetes insipidus has been described in young dogs. Dx by signs, rule-out of other causes, water-deprivation test, ADH response test. Nephrogenic diabetes insipidus won't respond to exogenous ADH. Animals unable to drink or with restricted access to water are at risk for hypernatremia and secondary neurologic signs, including coma. |
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