| 英文描述 | Dermatomyositis usually affects collies, Shetland sheepdogs, and their crosses although it has also been seen in several other breeds. Skin lesions generally appear at 7-11 weeks and are first seen on the head, face, ears, and body areas subject to trauma, but might be generalized, including ulceration of the oral mucosa and footpads. Muscle signs appear at 13-19 weeks, and include trismus, decreased palpebral response, muscle atrophy, decreased jaw tone, hyperreflexia, megaesophagus and transient lameness. Signs often wax and wane. Muscle involvement is mild in Shelties. Diagnosis is based on signs, breed, muscle biopsy, and EMG. Can develop secondary pneumonia. Inherited as a dominant with variable expressivity in Collies. Epidermolysis bullosa is probably a mild form of this disease. |
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