| 英文描述 | Three related English Springer Spaniel dogs developed, from an early age, regurgitation, slowly progressive temporal muscle atrophy with partial trismus, and less pronounced generalized skeletal muscle atrophy (Holland et al.). There was dyserythropoetic anemia (intramedullary destruction and shorted life span for circulating abnormal cells, with abnormal erythroid cells in the bone marrow), polymyopathy with megaesophagus, and varying degrees of cardiomegaly. There was moderately severe microcytic, normochromic anemia with abnormal erythrocyte morphology and marked normoblastemia without appropriate reticulocytosis. The polymyopathy was characterized by noninflammatory, nonregenerative muscle fiber degeneration. The cardiac portion of this syndrome included dilation of right ventricle, pulmonary conus, and ascending aorta; there were no notable histopathologic changes in those structures (Holland et al.). |
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