| 英文描述 | Diabetes insipidus is usually due to lack of antidiuretic hormone, with the subsequent development of polyuria and polydipsia, and urine of consistently low specific gravity even in the face of water deprivation. Has been described in the cow, horse, and sheep, but is very rare in large animals. Diagnosed by water deprivation and vasopressin response tests. Nephrogenic diabetes insipidus, in which there is insensitivity of the collecting duct epithelial cells to vasopressin, was described in horses. In the nephrogenic form there is an inability to concentrate urine in response to water deprivation, infusion of hypertonic saline, or exogenous vasopressin, and there is a normal increase in plasma vasopressin after water deprivation. |
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