| 中文名稱 | 幼犬及小貓的小腦退變 |
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| 英文名稱 | Cerebellar degeneration in puppies and kittens |
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| 建立日期 | 2007/11/01 |
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| 更新日期 | 2007/11/01 |
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| 中文描述 | 在一窩獵兔犬和3 窩薩摩耶犬中發現的一種小腦疾病,小腦的顆粒層裡會有腫脹的柏金式神經元的軸突.獵兔犬幼犬也會有小腦退化的後遺症,在驗屍時可發現退化的柏金式神經元.原因是未知的。診斷需要組織病理學.小狗的臨床症狀發生在開始走路的時候,在有些病例不會變嚴重或是只有輕微的變嚴重.但在其他時候就會無情緩慢的越變越嚴重.在貓會有遺傳性的漸進式小腦退化,臨床症狀大約發生在兩個月大,在之後的1-2.5個月會越來越嚴重但還不致命.在組織上可看到柏金式細胞退化的變化.(Inada et al.). |
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| 英文描述 | A cerebellar disease characterized histologically by swollen axons of Purkinje neurons in the granule layer has been seen in one litter of Beagles and three litters of Samoyeds. A syndrome of cerebellar degeneration in beagle pups with evidence of Purkinge cell degeneration at necropsy has also been described. The causes are unknown. Dx requires histopathology. The clinical signs are present with the pups begin to walk and are not progressive or only slightly progressive in some cases, while in others there is relentless slow progresssion. A hereditary, progressive cerebellar degeneration was described in cats. Clinical signs began at about 2 months of age, and were progressive but not fatal over the next 1-2.5 months. On histology degenerative changes of Purkinje cells was marked (Inada et al.). |
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