| 中文名稱 | 幼犬貓的GM1神經節苷脂儲積症 |
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| 英文名稱 | Gm1 gangliosidosis in young cats and dogs |
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| 建立日期 | 2007/11/01 |
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| 更新日期 | 2007/11/01 |
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| 中文描述 | GM1神經節甘脂儲積症是一種溶體儲存疾病由酸性β-半乳糖酶的缺乏所引起的。 已經被在英國斯普林格的長毛垂耳小狗,Portugese Water Dogs,Alaskan Huskies, Shiba,和混種小獵犬報告，和暹羅貓，Korat 和家畜短毛貓一樣。導致GM1神經節糖甘累積在神經元,以及臨床的病徵開始在少些月齡時。也許被視為一種隱性正染色體特點遺傳。透過酵素研究和組織學的組織診斷。在血液抹片裡也許會有淋巴細胞真空化。病徵是越發嚴重的。 在貓裡可能有角膜不透明和視網膜的斑點。 |
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| 英文描述 | GM1 gangliosidosis is a lysosomal storage disease caused by a deficiency of acid beta-galactosidase. Has been reported in English Springer Spaniels, Portugese Water Dogs, Alaskan Huskies, Shiba, and mixed breed Beagles as well as Siamese, Korat, and domestic shorthaired cats. Leads to accumulation of GM1 ganglioside in neurons and clinical signs. Signs start at a few months of age. May be inherited as an autosomal recessive trait. Dx by enzyme studies and histology of tissue. There might be vaculolation of lymphocytes on blood films. Signs are progressive. There can be corneal opacity and retinal spots in cats. |
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