| 英文描述 | Renal amyloidosis is primarily a disease of the glomeruli in the dog, with accumulation in glomerular capillaries of amyloid protein. This compromises blood flow resulting in glomerular cell death. Amyloid may also be found in other areas of the kidney and body tissues; in Chinese Shar Pei dogs hepatic amyloidosis without clinically important renal involvement has been described. Severe pulmonary vascular amyloidosis was associated with right-ventricular hypertrophy in a dog. Amyloidosis is the result of an immunologic defect, the exact etiology of which is unclear. May follow chronic infection, neoplasia, or have no evident preceeding disease. Older animals predisposed. Dx by biopsy. Uncommon in cats, except in the Abyssinian breed. Affected Abyssinian cats are usually presented for veterinary care at 1-5 years of age; this disorder is probably widespread in the breed. Familial renal amyloidosis occurs in Chinese Shar Pei and Beagle dogs. Medullary disease is common in cats. Leukocytosis, lymphopenia, nonregenerative anemia, hypercholesterolemia, azotemia, hyperphosphatemia, metabolic acidosis, isosthenuria, clylindruria, and proteinemia are common in affected dogs. |
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