| 中文名稱 | 馬匹的血色素沉著病 |
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| 英文名稱 | Hemochromatosis in horses |
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| 建立日期 | 2007/11/01 |
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| 更新日期 | 2007/11/01 |
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| 中文描述 | 馬形成慢性肝病的臨床和生化症狀;有高值的天門冬氨酸氨基轉移酶,鹼性磷酸酶,γ-谷氨酰基轉移酶,琥珀酸脫氫酶以及膽紅素.當這疾病在一些案例促進,有肝腦症的證據.肝臟生檢表現嚴重的門脈週邊纖維化包含大量的血鐵質在肝細胞中,並且有較少程度的在巨噬細胞中.當測量一匹馬,肝鐵量高.血色沈著病以鐵在肝臟累積以及其他器官導致細胞毒性為特性,並且有血色沈著病的診斷會帶有肝纖維化被在這些馬中發現. |
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| 英文描述 | Horses developed clinical and biochemical signs of chronic liver disease; there were high values of AST, ALP, GGT, SDH and bilirubin. As the disease advanced in some cases there was evidence of hepatoencephalopathy. Liver biopsy showed severe periportal fibrosis containing large amounts of hemosiderin in the hepatocytes and to a lesser extent in the macrophages. When measured in one horse, liver iron was high. Hemochromatosis is characterized by an accumulation of iron in the liver and other organs leading to cellular toxicity, and a diagnosis of hemochromatosis with hepatic fibrosis was made in these horses. |
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