| 中文名稱 | 馬匹的高血鉀症性，正血鉀性，間歇性痲痺，偏癱，HYPP |
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| 英文名稱 | Hyperkalemic, normokalemic, periodic paralysis, paresis, in horses, hypp |
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| 建立日期 | 2007/11/01 |
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| 更新日期 | 2007/11/01 |
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| 中文描述 | 一系列的馬曾經被報告出有閒歇性的顫抖伴隨著血清高血鉀症.症狀通常最先出現在年輕動物,通常是1-5歲;一開始的症狀有肌強直,偶有瞬膜脫垂,有時會有肌肉無力.曾和疝痛和肌病混淆.咽喉機能障礙常見.受攻擊時血鉀上升,但肌酸激脢不變.曾有報告指出有此症候群的馬在某些臨床時期是正血鉀;家族史,餵食鉀的敏感性,肌電圖,馬納離子通道基因的DNA引子可被用來診斷.動物可能持續
站立,變虛弱或倒下.典型的發病會維持15-90分鐘.在純色馬種可能為顯性遺傳,在阿帕魯薩馬及Paints也曾有報告.肌電圖可用來診斷但無法顯示其臨床症狀. |
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| 英文描述 | A series of horses were described that developed intermittent episodes of tremors accompanied by high serum potassium levels. Signs are first seen in young animals, usually 1-5 years of age; they develop signs of apparent myotonia, occasionally with prolapse of the nictitating membrane, sometimes followed by flaccid weakness. This has been confused with colic or myopathy. Pharyngeal and laryngeal dysfunction are common. Serum potassium levels are elevated during an attack, but serum creatine kinase levels are not. There are also reports of horses affected with this syndrome that are normokalemic during some clinical episodes; family history, sensitivity to oral potassium challenge, electromyography, and a DNA probe for the equine sodium channel gene can be used to make the diagnosis in those cases. Animals may remain standing, become weak, or go down. A typical episode lasts 15 to 90 minutes. Inherited as an autosomal dominant in Quarter Horses and has also been described in Appaloosas and Paints. Electromyography can be used for diagnosis in horses not displaying clinical signs. |
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