| 中文名稱 | 馬匹藥物引起的免疫溶血性貧血 |
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| 英文名稱 | Drug associated immune hemolytic anemia in horses |
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| 建立日期 | 2007/11/01 |
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| 更新日期 | 2007/11/01 |
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| 中文描述 | 免疫溶血性貧血在馬部常見,通常伴隨其他疾病一起發生.免疫引起的貧血可能和給予盤尼西林有關,受影響的馬抗球蛋白測試(Coombs)呈陽性且有很高力價的IgG抗體,此抗體會為凝聚在有盤尼西林包覆的紅血球.抗盤尼西林抗體IgM在許多馬中會以很低的力價存在,但有些會有抗盤尼西林IgG抗體的特異反應.馬在給予trimethoprim-sulphamethoxazole後產生的免疫引起溶血性貧血在停藥後會貧血症狀改善. |
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| 英文描述 | Immune-mediated hemolytic anemia is uncommon in horses, and usually is seen accompanying other diseases. Immune-mediated anemia has been associated with the administration of penicillin, and affected horses had positive direct antiglobulin (Coombs) tests and high titers of IgG antibody that agglutinated penicillin-coated equine red cells. Antipenicillin antibody of the IgM class is present in low titer in many horses, but some appear to have an idiosyncratic reaction of antipenicillin IgG antibodies. A horse developed immune-mediated hemolytic anemia after administration of trimethoprim-sulphamethoxazole and the anemia resolved after the drugs were withdrawn. |
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