| 中文名稱 | 犬隻腎上腺皮質分泌不全，愛迪生氏症 |
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| 英文名稱 | Canine hypoadrenocorticism, addison's disease |
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| 建立日期 | 2007/11/01 |
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| 更新日期 | 2007/11/01 |
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| 中文描述 | 初級的腎上腺皮質分泌不全起因於腎上腺皮質的退化,而目前一般還不知道退化的原因.自體免疫導致發病被懷疑是發病的原因,在狗身上有基因的根據,雖然遺傳的模式目前還沒有確定.典型的症狀是影響年輕到中年的狗,母狗多於公狗.其他的原因包括了腫瘤形成,阻塞,結核病,莢膜組織孢子菌感染,酵母菌病,澱粉樣變性,或是administering o,p'-DDD等,所造成腎上腺皮質的破壞.次級的腎上腺皮質分泌不足起因於不足的ACH刺激使得下視丘及腦下垂體的損傷或是延遲分泌血漿糖皮質激素.診斷藉由病症,血液學檢查,血清電解液,心電圖,血漿中的腎上腺皮質類脂醇的檢查,ACH的反應檢查,尿中的類固醇檢查.急性嚴重的情況(腎上腺危症)可能是由於腎上腺的阻塞,或是慢性階段的終止.腎臟的衰竭常常會伴隨著一起出現.曾有記載腎上腺皮質分泌不全和甲狀腺分泌不足(多腺體綜合症)同時發生.巨食道也是有可能發生的. |
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| 英文描述 | Primary hypoadrenocorticism results from adrenal cortical failure, commonly atrophy of unknown etiology. An autoimmune pathogenesis is suspected and there is a genetic basis in dogs, although the mode of inheritance is undetermined. Typically affects young to middle aged dogs, females more than males. Other causes include destruction of the adrenal cortex by neoplasia, infarcts, or disease such as tuberculosis, histoplasmosis, blastomycosis, amyloidosis, or administering o,p'-DDD. Secondary hypoadrenocorticism due to insufficient ACTH stimulation results from hypothalamic or pituitary lesions or prolonged exogenous glucocorticoid administration. Dx by signs, CBC, serum electrolytes, EKG, plasma corticoids, ACTH response test, urinary steroids. Acute severe disease (adrenal crisis) may be due to adrenal infarction or termination of the chronic phase. Concurrent renal failure is common. There is a report of concurrent hypoadrenocorticism and hypothyroidism (polyglandular syndrome). Megaesophagus might occur. |
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